Recommendations

If you’re interested in the longevity field, here is a curated but personal list of books, VCs, startups and resources I find interesting.

Recommendations
IA generated image of a scientist and a technologist doing research

I've been interested in the longevity field for more than a decade but only recently I've came back to the community. I'll update this list as I discover more in my journey with longevity.

Books

If you're interested in understanding how to approach longevity from this practical perspective I highly encourage you to start with these books:

  • Longevity Simplified → Dr. Howard J. Luks, a board-certified orthopedic surgeon specializing in Sports Medicine, who writes straightforward, actionable longevity strategies
  • Exercised → why something we never evolved to do is healthy and rewarding

If you're new to the longevity field and want to learn more about the science of aging I highly encourage you to read any of these books:

VCs

In the last years, longevity has gone from a movement to an industry and investment activity is picking up rapidly. In 2021, the $3.8bn invested into longevity was more than double the investment in 2020. And in 2022 it was even bigger.

Longevity venture capital investment ($M)
  • Longevity Tech Fund  → invest in startups focused on healthy lifespan extension globally
  • The Longevity Fund → They back world class entrepreneurs developing therapeutic breakthroughs for age-related disease
  • LongeVC → an international venture capital firm investing in visionary biotech companies and founders. Focusing on seed and early-stage investment, their mission is to bring to market breakthrough biotech that will change lives and transform the nature of health
  • Longevity Vision Fund → they want to make longevity accessible and affordable by funding life extension breakthroughs
  • Apollo Health Ventures → develops interventions with the potential to prevent or reverse age-related diseases and extend healthy human lifespan
  • 100 plus capital → invest in companies positively impacting human longevity
  • Healthspan Capital → investing in longevity biotech ("LongBio") and regenerative medicine to extend healthy human lifespan
  • Methuselah Foundation → is a biomedical charity who puts the mission first and the money second. They bet early on people and projects that, with their significant incubation and strategic services, will produce remarkable results
  • Methuselah Fund → designed to accelerate results in the longevity field, extending the healthy human lifespan. Our success is measured by financial return on investments and furthering the mission, with the mission being the priority
  • Lifespan.io crowdfunding → promotes the advancement of medical technologies which will increase healthy human longevity
  • Forever healthy → funds cutting-edge research on molecular and cellular repair to combat the root causes of aging
  • Longevity Escape Velocity Foundation → works to proactively identify and address the most challenging obstacles on the path to the widespread availability of genuinely effective treatments to prevent and reverse human age-related disease
  • Bold Capital → invests in emerging science and technologies that will disrupt and democratize massive markets, creating innovative solutions to humanity’s greatest challenges
  • Breakout Ventures → invests in early-stage companies building bio-based solutions to dramatically improve human health and the sustainability of our planet
  • Continuum Health Ventures → early-stage venture capital fund that seeds, nurtures and accelerates the next generation of Digital Healthtech and Longevity startups that will focus on extending human healthspan
  • SENS Research Foundation → invests in the future of regenerative medicine by providing funding and support to promising biotechnology startups
  • Longevity Foundation → working to bring a new approach to medicine out of the laboratory and into the real world
  • Invivo Capital → focuses on investing in early-stage companies in the healthcare sector

Startups

I think we need different strategies and frameworks to research life extension so we can maximise our probabilities. I've been working in startups for most part of my career. Here is a list of startups (at least somehow related with longevity) that I find fascinating. This is a very personal list with no particular order.

  • Altos Labs → restore cell health and resilience through cellular rejuvenation programming to reverse disease, injury, and the disabilities
  • turn.bio → develops mRNA medicines that induce the body to heal itself by instructing specific cells to fight disease or repair damaged tissue
  • Retro Biosciences  → their mission is to increase healthy human lifespan by ten years. They have an initial funding in the amount of $180 million, which will take them to our first proofs of concept, and secure operation of the company through the decade
  • Rubedo → discovers and develops medicines to keep you biologically young by targeting the pathologic cells that drive aging
  • Gordian Biotechnologies → creating the first in vivo therapeutic screening platform to radically improve drug development for complex diseases of aging
  • Juvena Therapeutics → mapping secreted proteins to unmet medical needs. Their mission mission is to unlock the therapeutic potential of secreted proteins and to engineer them into life-saving therapeutics
  • Loyal → develop drugs intended to help dogs live longer, healthier lives
  • Epirium → is a biopharmaceutical company pioneering novel therapeutics that leverage our understanding of muscle biology, tissue regeneration and mitochondrial function to develop therapies that have potential for broad clinical applicability across multiple disease areas of high unmet need
  • Ora Biomedical → develops small molecule therapeutics that extend lifespan and delay chronic illness by targeting the underlying molecular mechanisms of aging
  • Unity Biotechnology → selectively eliminate or modulate senescent cells
  • Spring Discovery → gives scientists superpowers. We put world-leading technology and easy-to-use software in the hands of researchers working to understand and battle disease
  • Osin → induce the senescent cell to commit suicide
  • Mogling Bio → develop novel pharmacological approaches to rejuvenate old stem cells
  • Valo → technology company built to transform the drug discovery and development process using human-centric data and AI-powered computation
  • Calico → research and development company focused on better understand the biology that controls aging and lifespan
  • Insilico → accelerate drug discovery using artificial intelligence for every step of pharmaceutical research and development
  • Gero → utilize whole-exome sequencing data for in-human AI drug discovery
  • Celularity → develop off-the-shelf placental-derived allogeneic cell therapies
  • Dorian Therapeutics → research and develop senoblockers, a new class of therapeutics that can rejuvenate cells and tissues
  • Cyclarityx → develops easy-to-use drugs that prevent common age-related conditions such as atherosclerosis, heart-attack and stroke
  • Revel → apply enzymes to repair and develop cures for patients suffering from aging and age-related disease.
  • Life Biosciences → develop therapeutics with the potential to prevent, treat, and/or reverse multiple aging-related diseases, each with critical unmet medical needs
  • Neuralink → build better tools intended to communicate with the brain
  • Biolytica → offer a platform that combines and contextualises genomics, pharmacogenomics, epigenetics, biomarkers, wearable device data, lifestyle and nutrition to allow new insights into human health from a holistic perspective
  • Deepcell → offer an AI-powered imaging and microfluidics platform that identifies and isolates viable cells based on morphological distinctions for use in translational research, diagnostic testing, and therapeutics
  • Cradle → help biologists design improved proteins in record time using powerful prediction algorithms and AI design suggestions
  • Timeline nutrition → develop supplements based on a precise dose of the rare Urolithin A molecule and clinically-proven to revitalize mitochondria
  • Kutanios → prevent many skin conditions by transferring the beneficial properties of HDL particles (good cholesterol) to skincare products
  • Juvlabs → research and develop supplements that support healthy aging and therapies that prevent aging and age-related disease
  • Biolinq → developing a new bio wearable by using an array of electrochemical sensors so small you can barely feel them
  • Cambrian → is building the medicines that will redefine healthcare in the 21st century – therapeutics to lengthen healthspan, the period of life spent in good health
  • Rejuveron → a clinical-stage biotechnology company creating therapies to improve healthy aging. Its experienced drug discovery and development team applies a deep understanding of the biology of aging, alongside technological advances in biopharmaceutical R&D, to progress a new generation of medicines that will help people to age better and live longer
  • Cleara → targeting cellular senescence to extend human healthspan at old age and to counteract late stage cancer
  • Samsara Therapeutics → biopharmaceutical company aiming to discover first-in-class therapeutics that treat rare genetic and neurodegenerative disease, and extend healthy lifespan
  • Mitrix → grow healthy mitochondria in bioreactors and then transfuse them into the patient to bolster energy production and regenerate aged or dysfunctional tissues
  • Senisca → developing new approaches to reverse cellular senescence - senotherapeutic interventions to target the diseases and aesthetic signs of ageing
  • Mito Therapeutics → developing a pipeline of first-in-class first-in-target small molecules for diseases involving mitochondrial dysfunction
  • Elevian → develops regenerative medicines that target the root-cause of aging processes. Elevian has identified blood factors that regulate aging and stimulate the body’s natural repair and regeneration mechanisms and is developing biotherapeutics targeted at these factors
  • Deep Longevity → deep learning for aging research specializing in development of biomarkers of aging
  • Decidous Therapeutics → developing novel immunotherapies to ablate senescent cells and systemically treat age related diseases
  • Zero → provides an app to improve metabolic wellbeing, mostly through fasting
  • Viome → performs strain level identification of the gut microbiome to promote better health outcomes
  • Oura → produces a ring wearable that actively monitors the physiological responses of the body and is the leading commercial sleep monitor in market today

I usually write about both, practical longevity and how I put it in practice in my own life but also about advancements in the science behind slowing down aging and even rejuvenation therapies. If you'd like to join me in this journey, just subscribe and share it just with one person that would find this interesting.

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Jamie Larson
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